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The uptake of microsystems in point of care diagnostics has been relatively slow. This is for a number of reasons, but a principal one is that not all of the elements in the analysis chain are robust or easily manufactureable. Examples of these are sample preparation and rapid DNA extraction, amplification and detection within a microsystem. Working with commercial partners the microengineering component of the project will indentify and investigate a number of these key technological challenges that are barriers to developing rapid point of care microsystems based polymicrobial STI diagnostics. An important aim is to produce a “front-end” STI sample processing system, usable by industry to evaluate novel bio-sensing technologies that are rapidly emerging from nanotechnology and semiconductor research and thus be an aid to translation of promising diagnostics . In addition work will also focus on the control elements and wireless communications required to enable integration into a larger system.